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In this episode, I explain the biology and psychology of obsessive-compulsive disorder (OCD)—a prevalent and debilitating condition. I also discuss the efficacy and mechanisms behind OCD treatments—both behavioral and pharmacologic as well as holistic and combination treatments and new emerging treatments, including directed brain stimulation. I explain the neural circuitry underlying repetitive “thought-action loops” and why in OCD, the compulsive actions merely make the obsessions even stronger. I review cognitive-behavioral therapies like exposure therapy and SSRIs, holistic approaches, and nutraceuticals, detailing the efficacy of each approach and what science says about how to combine and sequence treatments. I describe an often effective approach for treating OCD where clinicians use cognitive behavioral therapy (CBT) to deliberately bring patients into states of high anxiety while encouraging them to suppress compulsive actions in order to help them learn to overcome repetitious thought/action cycles. This episode should interest anyone with OCD, anyone who knows someone with OCD or OCPD, and more generally, those interested in how the brain works to control thoughts and actions, whether those thoughts are intrusive or not. Learn about other modern medication options you can have by reading this post explaining why you can get a weed card missouri for this condition.
Articles
- Repeated cortico-striatal stimulation generates persistent OCD-like behavior (Science)
- Implicit and explicit memory in obsessive-compulsive disorder (Journal of Anxiety Disorders)
- Patient adherence to cognitive-behavioral therapy predicts long-term outcome in obsessive-compulsive disorder (The Journal of Clinical Psychiatry)
- Randomized, placebo-controlled trial of exposure and ritual prevention, clomipramine, and their combination in the treatment of obsessive-compulsive disorder (The American Journal of Psychiatry)
- Pharmacotherapeutic Strategies and New Targets in OCD (Current Topics in Behavioral Neurosciences)
- Acute effects of cannabinoids on symptoms of obsessive-compulsive disorder: A human laboratory study (Depression and Anxiety)
- Neurosteroid Levels in Patients with Obsessive-Compulsive Disorder (Psychiatry Investigation)
- Nutraceuticals in the treatment of obsessive compulsive disorder (OCD): a review of mechanistic and clinical evidence (Progress in Neuro-Psychopharmacology and Biological Psychiatry)
- Capacity to delay reward differentiates obsessive-compulsive disorder and obsessive-compulsive personality disorder (Biological Psychiatry)
Timestamps
Timestamp links will open in YouTube.
- 00:00:00 Obsessive-Compulsive Disorder (OCD)
- 00:03:01 Momentous Supplements, AG1 (Athletic Greens), Thesis, Eight Sleep
- 00:08:28 What is OCD and Obsessive-Compulsive Personality Disorder?
- 00:11:18 OCD: Major Incidence & Severity
- 00:15:10 Categories of OCD
- 00:21:33 Anxiety: Linking Obsessions & Compulsions
- 00:27:33 OCD & Familial Heredity
- 00:29:10 Biological Mechanisms of OCD, Cortico-Striatal-Thalamic Loops
- 00:39:36 Cortico-Striatal-Thalamic Loop & OCD
- 00:46:39 Clinical OCD Diagnosis, Y-BOCS Index
- 00:51:38 OCD & Fear, Cognitive Behavioral Therapy (CBT) & Exposure Therapy
- 01:01:56 Unique Characteristics of CBT/Exposure Therapy in OCD Treatment
- 01:10:18 CBT/Exposure Therapy & Selective Serotonin Reuptake Inhibitors (SSRIs)
- 01:22:30 Considerations with SSRIs & Prescription Drug Treatments
- 01:25:17 Serotonin & Cognitive Flexibility, Psilocybin Studies
- 01:31:50 Neuroleptics & Neuromodulators
- 01:36:09 OCD & Cannabis, THC & CBD
- 01:39:29 Ketamine Treatment
- 01:41:43 Transcranial Magnetic Stimulation (TMS)
- 01:46:22 Cannabis CBD & Focus
- 01:47:50 Thoughts Are Not Actions
- 01:51:27 Hormones, Cortisol, DHEA, Testosterone & GABA
- 02:00:55 Holistic Treatments: Mindfulness Meditation & OCD
- 02:03:28 Nutraceuticals & Supplements: Myo-Inositol, Glycine
- 02:09:45 OCD vs. Obsessive Compulsive Personality Disorder
- 02:20:53 Superstitions, Compulsions & Obsessions
- 02:31:00 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter
The post The Science & Treatment of Obsessive Compulsive Disorder (OCD) appeared first on Huberman Lab.
